Huperzine a dopamine reddit. I used to take Huperzine A a couple years ago and noticed a huge mood improvement not a big antidepressant kind of effect but just in the mood effect. Although ALA was historically used as Sep 18, 2006 · The time course of cortical acetylcholinesterase (AChE) inhibition with the 3 inhibitors mirrored the increases of ACh at the same dose. New comments cannot be posted and votes cannot be cast. It has a huge, negative effect on my sleep when I take it too late. 4 Huperzine A helps to fight depression. I get so nauseated that I'm borderline going to vomit. Orally ingested huperzine A appears in the blood within 15-minutes and reaches peak levels by 60-minutes while remaining in the system for at least 12-hours . I found a way to increase dopamine, but block the conversion to Norepinephrine! Discussion. I recently got Huperzine A from Life Extension, which has 200mcg per capsule. 2 Huperzine A protects your brain. You should cycle it. Experience. true. I have had about 6-7 tubs of this pre workout, sometimes consistent sometimes not. Huperzine A (Hup A) is a purified alkaloid compound extracted from a club moss called Huperzia serrata. I used maybe only 50mcg of Huperzine-A. I were not fully aware of HupA's mechanism of action at the time. I had consumed 25. 3 Huperzine A can make you smarter. I only notice improvement if/when I test myself. Making it stupid ineffective with my dreams. Suggestion for a strong antioxidant supplement stack: vitamins: C 2 grams, riboflavin (B2) 50 mg, B6 , folate (B9) 800 mcg, B12 100 mcg. Huperzine A is only a weak NMDA antagoist, probably Currently alternating between taking 200mcg Huperzine A one day (which raises acetylcholine by inhibiting acetylcholinesterase) with a few additional capsules of 250mg Alpha GPC as needed throughout the day and the days in between just taking 1g of Alpha GPC 2x-4x throughout the day. Negative and cognitive symptoms are thought to be in part caused by low dopamine in PFC, in the mesocortical dopamine pathway. Perhaps think about trying other lucid enhancers like mugwort, b6. ACh in itself is a neurotransmitter that's very involved with memory (a lot of The mix 350mg caf / 100 mg DMHA / 50 mg DMAA is amazing. Sometimes it's only temporary, sometimes it Sep 28, 2022 · Huperzine-A is a cognitive enhancer that inhibits an enzyme that degrades the learning neurotransmitter, acetylcholine; due to this, a relative increase occurs. Do not look at the crazy dosages some companies have or claim they have. ref. I love Huperzine A, especially for lucid dreaming and memory. - Enjoy the music (Hardstyle/ rap / hard rock) Other effects: - Need to drink a lot. Dosage. 5 μmol/kg) and donepezil (5. So in that way, the two are at cross odds and if you like one of them, there is a good chance that the other one will be the opposite Personally, I take huperzine A no more than once every two days, in my case greatly affects the amount of information processed visually. It most definitely worked. Even that article says: “That said, the decision to unplug and detach from certain impulsive behaviors may come with some health benefits, one of which is the potential for heightened focus and greater mental clarity. Creativity and reaction speed increase too. Extreme motivation, focus, less anxiety and also this quick thing u describe. Concerta 54mg, B Complex, alpha gpc 300mg, L Tyrosine 1g, Huperzine A, 100mg Ubiquinol, 500mg Lions mane, 300mg Bacopa, 200mg Gotu Kola, 1g Cordyceps Posted by u/[Deleted Account] - 7 votes and 5 comments Lokzo55. ALA has also been reported to cause upregulation of NMDA receptors in addition to blockade of dopamine receptors (Molz and Schroder 2017). 4 µmol/kg) was associated with a significantly increased release of dopamine (DA) in the mPFC or hippocampus. 1 Huperzine A may help prevent Alzheimer’s disease. Dopamine is often distracting, and may be a hindrance for some people from achieving their goals. Like most of you will think of Beta-Alanine is merely a bodybuilding supplement, there is far more under the hood to this naturally occuring non-essential amino 200mcg Huperzine, 200mg Caffeine, 200mg L-Theanine. Stick with some racetams if you want more memory retention. I take 100mcg in the morning, the sooner the better. * Connect with a community of dream enthusiasts. 2011; Shay et al. So to LD, you need lots and lots of techniques and knowledge of how-to. I felt not only tired, but unmotivated. Take it in the morning. Crypto I am using Huperzine A 250mcg every 2 days and I just found a bottle or L-Theanine pills (225 mg) lying around. Compared with placebo, Huperzine A showed a significant beneficial effect on the improvement of cognitive function as measured by Mini-Mental State Examination (MMSE) at 8 weeks, 12 weeks and 16 weeks, and by Hastgawa Dementia Scale (HDS) and Wechsler Memory ADMIN MOD. Zyban. - No wear (I go to my muscle failure on the bench without sign of wearness before, on the end of training) - Good mood ++. This reminded me of the way I felt when I was going through nicotine withdrawals months ago. Alpha GPC is highly effective. Serotonin downregulates acetylcholine. Try at John's worth instead, yes it's mainly a antidepressant, but man this stuff boost me also similar like huperzine. Matcha is usually great whenever, only should be avoided when hyper sensitive to caffeine etc. Huperzine is acetylcholinesterase inhibitor (AChEI) which in short, stops an enzyme, acetylcholinesterase, from metabolizing acetylcholine, leaving it to buzz around synapses longer. I was thinking to add 2 Theanine pills daily also to have better effects from my coffee intake. 750mg DMAE bitartrate. High levels of acetylcholine have been linked to mood deterioration. 20 RCTs including 1823 participants were included. * Keep a dream journal. 4. Its like taking acid in the dream world. In theory, there should be no reason to supplement but what if someone is soo depleted from dopamine that restoring levels could be achieved quicker by supplementing directly with L-dopa for a short amount of time to help it a long. Ginkgo being significantly cheaper per pill. The Noopept is a nootropic and the Alpha-GPC is to support the Noopept as a precursor to acetylcholine. Some of these side effects, such as angle-closure glaucoma or heart attack, may have lifelong complications. Brewers Yeast is 120mcg of B1, 40mcg B2, and 300mcg of Niacin. Idk. Huperzine A or Ginkgo Biloba for Cholinergic Improvement. I never used it more frequently than once every five days. Thus more dopamine gets to the brain (the desired effect) and less to the rest of the body (where it can cause bad side effects). Posted by u/CamerataDev - 5 votes and 2 comments The coffee and modafinil are stimulants, and give me motivation. ADMIN MOD. Uridine is a cheaper alternative. It's the archetypal nootropic. The negative was that I seemed to become more and more tired with each day. Every retail stack Ive seen with it starts at 200mcg and I havent noticed any poor effects from taking 600mcg daily. Huperzine and the other two have diff modes of action. Haven't tried it but one of the things Lions Mane increases is serotonin and is a sleepiness inducer. Here we are a year later. Yes, they have risks but those risks are known. Looking forward to hearing from you. Huperzine A specifically inhibits the G4 isoform of acetylcholinesterase which is highly prevalent in mammalian brains. 5 µmol/kg) and donepezil (5. I stopped taking huperzine a as even spacing usage out 4 days or 48 hours I still developed a tolerance. That being said, we do carry huperzine A powder. L-Tyrosine – Indirectly boosts dopamine, increasing motor function, verbal fluency, critical thinking etc. May need to be cycled. " 9. A pill like Huperzine-A may make LD more likely to occur, but controlling it is a totally different matter. 4 μmol/kg) was associated with a significantly increased release of dopamine (DA) in the mPFC or hippocampus. SOME type of break is needed, regardless. Huperzine A Huperzine A is a potent AChEIs, which is naturally derived from Huperzia serrata, and used in the management of Alzheimer’s disease. Defecation. Usually huperzine a comes from a 1% extract of huperzia serrata, which would make 10mg of extract a typical 100mcg dose of hup a. * Share your dreams. But 150-200 mcg literally causes me to slur my words, have uncontrollable muscle twitches all over my body, salivate like crazy and have intense anxiety attacks and insomnia, not to mention balance issues, but it's really hit and miss. One of the ingredients in that pre is 50mcg of huperzine a. Just looking for that memory boost to help me with my exams. Oct 29, 2021 · Huperzine A (HupA), an alkaloid found in the club moss Huperzia serrata, has been used for centuries in Chinese folk medicine to treat dementia. Once they were over, I stopped it cold turkey, which seems to have been a bad idea as my heart rate upon waking up lately has been insanely high and I’ve been feeling Huperzine A can be dangerous in certain combinations and doses, I would do a LOOOT of research before messing with it. In animal studies, huperzine A is found to reduce neuronal inflammation, oxidative stress, and enhance behavioral recovery after repetitive traumatic brain injury in mice (Mei et al. Huperzine reduces the reuptake, meaning you get more usage out of the choline before it gets cycled into the metabolism. After 2 weeks of continued daily use I have noted the following effects: -Increased mental/physical energy -Reduced fatigue -Alertness increases, similar to Theanine but less GABAergic. The primary mechanism of huperzine a involving memory is that it is an acetylcholinesterase inhibitor which limits the production of acetylcholine, the chemical which heavily effects working memory. 1mg desmethyldeprenyl (nordeprenyl) earlier and was feeling anxious, so I decided to test it out. From the faq: Huperzine A may cause 'transient gastrointestinal dysfunction and elevations of ALT'. Huperzine A is one of those old school supplements that people have used for long time like creatine kind of. I am looking to improve memory and cognition, but there are some side affects of huperzine a, most notably slowed heart rate, that make me hesitant to try it. So we know that Huperzine A Increases acetylcholine which overall is good for memory. Stimulants are considered the gold standard for effectiveness in ADHD. Huperzine A = for Acetylcholine. You can Google for an answer, but probably best to go with the more conservative/less desirable option of what you find. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , Wellbutrin SR and XL Helps tremendously with memorization. I was doing research and I found that Theanine increases glutamate and is an NMDA agonist, while Acetylcholine should do the opposite. I am on a budget and want a OTC acetylcholinesterase inhibitor, and I heard that those are the only valid ones to use. It has dopaminergic effects as well as acetylcholine. I’m just wondering if an increase of acetylcholine could have possible effects on depression in any way. And though we know that the dosage is low, the powder is diluted to a 1% huperzine A concentration, making it fairly easy to ALA and its reduced form are considered natural free radical scavengers and thus act as antioxidant and anti-inflammatory agents (Goraca et al. * Request interpretation of your dreams. 2009). Huperzine A is also reversible [4], but I haven't seen any direct data about whether it causes upregulation. The result was a considerable increase in the probability of lucidity on the night taken. Huperzine-A – Acts as a 'status buff extender' to CDP/Alpha-GPC by inhibiting the reuptake of acetylcholine, increasing the amount of time Huperzine A is seriously nauseating. Thanks for the info. Very good to mix for a study session The addition of Huperzine or Matcha is just nice as opposed to corrective to the deleterious effects. * Post links to interesting sites or videos related to dreams. As I understand it, huperzine a supposedly improves memory and cognition by preventing/slowing the breaking down of choline/acetylcholine in the brain. I have no day-time experience with Huperzine A. XenuEtrawl. My short term memory increase a lot. I calculated that that’s around 120 days of taking around 50-100 mcg of huperzine a. N-acetyl L-tyrosine = mainly for Dopamine & Thyroid hormones. Idk much about it but I know when I was reading it I decided against it. Many other posters get the same effect from alpha GPC and citicholine. The SNS is 99% pure extract, but the Huperzine A content is not guaranteed to be 1%. Chromium is variable in brewers yeast, but I'd say 200mcg to 400mcg. How this supplement alone isn’t enough for any nootropic user boggles my mind. In other words, Huperzine A might not be as linear as Galantamine in regards to lucid dream vividness or length. It's weird that it doesn't state the potency explicitly, but I've only ever seen 1% from what I recall. , 2017). This raises your baseline dopamine for several hours so you can get things done. Sort by: I take Huperzine A without a choline source (except for some cooked eggs sometimes) and sometimes I take maca and the things get fixed (some minor side effects) 100mcg huperzine A is pretty normal dose for non-clinical settings, def not "very low". Make sure to take it after WBTB. So, in the last week or so I have been experimenting with Beta-Alanine. Use at your discretion. Lacrimation: stimulation of the lacrimal glands (tearing) Urination: relaxation of the internal sphincter muscle of urethra, and contraction of the detrusor muscles. • 2 yr. I'm pretty sure NMDA activity contributes to dream vividness, but have no way to prove it. I can also unserstand much better and this lead to long term memory benefit as well because you understand better. 334K subscribers in the Supplements community. B12. Refer and Earn. Its secondary depressant effects are through GABA-b. Interestingly, reference [4] mentions huperzine B, which it says "is less potent and selective than Hup A, but it has higher therapeutic index and other positive benefits. There is practically no discernible feeling from it. L-Theanine – Increases focus, reduces anxiety, increases creativity/confidence. Huperzine is supposed to increase the level of acetylcholine in the brain, so it's no surprise that one might help with memory. Once or twice a week max otherwose your body will get used to it and it wont be as effective. I have Gotu Kola extract on hand but was skeptical of this one (despite reading so many glowing reports). The first time I had DMAE was a rather incredible experience. " Yesterday I read about Huperzine A extract supplement that inhibits reuptake of ACh which should increase dopamine in the PFC and Hippocampus improving general cognition especially memory according to studies. I believe the 1% refers to exactly how much Huperzine A is in the extract, which is 99% pure extract (in liftmode's case). Whilst not typically considered a nootropic, Gynostemma has been really remarkable for me. The biological Dec 15, 2022 · Increases Norepinephrine and Dopamine – but not Serotonin. This other drug doesn't have an established risk profile and hasn't been proved effective. I personally love Cognizin/citicoline. It increases motivation and focus. I would like to know if any males were prescribed Cabergoline or any other dopamine agonist in response to a diagnosis of Ejaculatory Anhedonia? It is my humble (non scientific) opinion that prolactin holds the keys to this disorder I can cite one specific study where men were given a dopamine agonist such as caber in one arm and a dopamine Supplements for increasing dopamine: L-tyrosine Mucuna Pruriens Phenylethylamine Maca root Huperzine A Supplements that decrease dopamine. So what is the point of knowing that you're dreaming just to also realize you cannot control it to your liking? So if you try it, be aware to start with the smallest dose or the dose that makes you feel good. I would just start at the recommended effective dose of 100mcg. ago. Huperzine-A acts as an acetylcholinesterase (AChE) inhibitor which is an enzyme that breaks down the neurotransmitter acetylcholine. A subreddit designed for discussion of supplements and nutraceuticals; for health, performance, or any… Sort by: NootropicsDepotGuru. Business, Economics, and Finance. :) Archived post. Gotu Kola experience. Rather than having more choline available for chemical processes, you have less because the faster depletion of acetylcholine requires that you make more of it. Dr-Rumack. Wellbutrin -Bupropion , all things related to this antidepressant. •. However, that being said, a great idea would be to add huperzine to a choline, uridine, DHA, and EPA source. I am using Huperzine A 250mcg every 2 days and I just found a bottle or L-Theanine pills (225 mg) lying around. If it makes you feel bad, reduce the dose. The methodological quality of most included trials had a high risk of bias. Huperzine has also positive effects on the GABA-ergic System and apparently the dopamine system. The effects of this alkaloid have been attributed to its ability to inhibit the cholinergic enzyme acetylcholinesterase (AChE), acting as an acetylcholinesterase inhibitor (AChEI). Aug 1, 2021 · Huperzine A forms two hydrogen bonds within the gorge of AChE and has a longer dissociation time than what is typical of most therapeutic AChEIs (6, 32). Not sure if other brands would be better. That being said: "Huperzine A appears to have no tolerance effect, as repeated doses appear to demonstrate similar AChE inhibition as that of a single dose in a rodent model [22]. Welcome to the Reddit Dreams community! * Ask questions and learn about dreams. So dopamine will be downregulated whatever you take to boost dopamine, until you improve your oxidation status. minerals: zinc 20 mg, copper 2 mg (10% of zinc amount to prevent copper depletion, although Cu is Huperzine A overdose experience. Feb 5, 2022 · For as much as, medicinal plant based pharmaco-therapies are emerging as potential candidates for AD treatment keeping the efficacy and safety parameters in terms of toxicity and side effects into consideration. Sort by: Huperzine A (HupA), a novel alkaloid isolated from the Chinese herb Huperzia serrata, is a potent, highly specific and reversible inhibitor of acetylcholinesterase (AChE). Even at 300mg this supplement has had a measured impact on my performance in Call of Duty, a highly demanding video game. Effects : - Boost of energy. Several studies have reported But eventually the subdued and I felt like it wasn't working as much, didn't notice the same effects at all after a few weeks. Inhibiting acetylcholinesterase means more acetylcholine and a more powerful working memory. 200 micrograms gave me mild cholinergic toxicity with muscle twitches and word slurring. 1. This gives you small peaks of dopamine that train you to enjoy what your doing, even if right now it's kinda boring. I haven’t done research until now and I am worried because . I feel like it just makes me overall smarter. That's a fairly safe, low dose. All in all, liftmodes is a more reliable product and SNS is most likely using the 99% statement as a marketing scheme. Almost every day I would take 1 and a half to 2 scoops. You could try taking alpha gpc or choline with your Huperzine as they work synergistically and dont take every night. Super negative effects from Huperzine A. It makes my dream far more vivid and interesting as well. Suicidality, worsening of depression, mood changes, mania, hostility, and other neuropsychiatric events can occur with the use of bupropion. You have to take it very early in the day, as it has a very long half life, and also recommend a decent intense workout at some point in the day as again alot of athletes used it for that. The marked elevation of ACh after oral administration of huperzine A (0. Herbs and Nutrients for the Mind: A Guide to Natural Brain Enhancers. 2. I didnt know there was a starting dose for it. It’s very common patients prescribed sodium oxybate for narcolepsy to shoot awake as it needs dosing every 2-4 hours, once blood levels drop below sedative levels it uncovers the stimulant properties. I ended up taking quite a good number of pills over a course of a week. GameStop Moderna Pfizer Johnson & Johnson AstraZeneca Walgreens Best Buy Novavax SpaceX Tesla. I have chronically and acutely stimulated dopamine my entire life. * The latest news and info about dreams. Any Huperzine supplementation is rare and generally stems from a desire for the "slightly different yet generally familiar" choline stimulation. 5 Huperzine A aids the growth of neural cells. Huperzine A in combination with a low dose of armodafinil seems to reliably enhance my overall cognition, verbal acuity, and ability to articulate myself in intelligent conversation. I've used it and planning on ordering some again. ^ Meletis CD, Barke JE (2004). These properties seem to warrant Perhaps triggering autoimmune conditions or causing limp dick. According to one animal study, huperzine A was reported to increase the levels of norepinephrine and dopamine in the brains of rats, while not affecting the levels of serotonin [ 9 ]. 3 Amazing Benefits of Huperzine A. 6 It can improve your energy. I have also ADHD and huperzine a works also wonders for me. I find phenylpiracetam to work well, and its a minor NE and DA reuptake inhibitor which should NAC (low dose only; 400-600 mg before and redose when comedown becomes uncomfortable): NAC aids in reducing dopamine depletion from amps and reduces the comedown significantly for me Huperzine A: Increased euphoria and cognitive effects, brings back the magic for me. Huperzine A is a NMDA antagonist, and higher dosages might effect dreaming in less predicable ways. If you take it daily (weekdays/weekends), I would guess at least a week or two for every 2ish months. If you're just starting with Huperzine I'd recommend 100 or 50 mcg of huperzine first, 100mg of caffeine, 100 L-Theanine stack. Today like an absolute dumbass I misread the directions in a hurry (as I was late for kickboxing class) on my bulk huperzine A powder I ordered from amazon (I wanted to try it because I heard of increased muscle contraction strength) and took about a 1/4th of a teaspoon of powder, I'm guessing around 500mgs. AGPC/Cognizin adds to choline. I have access to hydroxyzine because I'm prescribed it, but I'm trying to avoid antihistamines for now on. Ad the previous poster notes, this means something entirely different than being a dopamine reuptake inhibitor, like Sabroxy (standardized to 10% Oroxylin A) Aug 1, 2021 · Huperzine A forms two hydrogen bonds within the gorge of AChE and has a longer dissociation time than what is typical of most therapeutic AChEIs (6, 32). Very strong. Huperzine A is a reversible acetylcholinesterase inhibitor (reversible having a specific pharmaceutical definition here) and NMDA receptor antagonist. I’d been taking Huperzine A 200 MCG everyday for like a week. I was taking it 250mg/2× a day. Sep 23, 2013 · Results. For about 3 days in a row, dissolved in alcohol, allowed to sit under the tongue for a while (you might not enjoy doing this), then swallowed into an empty stomach. 1. This is because carbidopa prevents the metabolism of levodopa into dopamine, but doesn't itself cross the blood-brain barrier, effectively blocking the effect only outside the brain. I assume based on common sense and also the existence of enteric coated Gotu Kola product that About an hour ago I took a second 200 mcg dose of huperzine, before realizing I'd already had some today. Now I'm a bit worried because although the upper limit is 3500 mg choline a day for adults--I know huperzine inhibits breakdown. Alprazolam is the best example because it does possess unique dopaminergic properties Stack for work. Melatonin ***Note - When you increase dopamine, it's accompanied by a crash in the opposite direction -- there's no getting around this. Emesis: Vomiting [2] Figured this was worth mentioning; it doesn't really alleviate DP directly but it's a good way to offset some of the cognitive issues. Any suggestions to help with the side effect of nausea while taking Huperzine A? I'm only taking 200 mcg. The reason is that Huperzine A is an Acetylcholinesterase inhibitor, and as choline is indeed a nutrient you can overdose on, I would actually discourage to simultaneously use both at the same time, or at the least be very conscious of how much you take of either. These properties seem to warrant And Huperzine A is a powerful compound, don't underestimate it just because it's natural. It belongs to the cholinergics class of molecules, and may be useful in fighting cognitive decline in the elderly. Start overloading yourself with excess dopamine and your body will start down-regulating dopamine production, receptors, or both. A well researched Noot, goes well with Racetams and a choline source. This is something we could look into, however the demand for huperzine A is relatively low, so this may not be a realistic possibility. elevation of ACh after oral administration of huperzine A (0. As most people recommend 50mcg for Hup A Warm up through movement after. Partial control vs total control. Gastrointestinal distress: Smooth muscle tone changes causing gastrointestinal problems, including cramping. Some ppl think it ups rem sleep. Normally I would use Choline Bitartrate at the same time. Discussion. Huperzine A is pretty strong, with 200mcg I definitely feel uncomfortable and Huperzine causes your brain to deplete acetylcholine faster. I needed to stop taking st John's worth because my stomach pills no longer worked with it. Gingko biloba is believed to increase blood flow in the brain and aid memory, and the amino acids are precursors to the neurotransmitter dopamine. Hate to necro this thread. In this case, take too much of an acetylcholinesterase inhibitor, and your body will start producing more acetylcholinesterase, as such breaking down acetylcholine faster and having the opposite effect. Say a couple of days or a week? ADHD/ASD here. 3. Verdict: I believe Huperzine is a great nootropic for people who want to improve their memory and learning, but take a low dosage (up to 100 mcg) and regularly cycle it to avoid side effects. But Huperzine A helps preserve acetylcholine and is a wakeness inducer. Look for things you're grateful for (about what your doing) while studying/working. Maybe 75mcg one day. PRL-8-52 is more mysterious. However, a lot more studies will be needed to know if these effects apply to the human brain as well. I thought I would preface this by crediting Alpha GPC as the best supplement I’ve taken. Combining it with an antidepressant that decreases the seizure threshold is something I personally wouldn't have the courage to experiment with, at least not after my 750mg DMAE bitartrate. Dec 15, 2022 · Increases Norepinephrine and Dopamine – but not Serotonin. so kd qs el cv qt ah gv vh cp